Detalhe da pesquisa
1.
APOE3ch alters microglial response and suppresses Aß-induced tau seeding and spread.
Cell
; 187(2): 428-445.e20, 2024 01 18.
Artigo
Inglês
| MEDLINE | ID: mdl-38086389
2.
APOE mediated neuroinflammation and neurodegeneration in Alzheimer's disease.
Semin Immunol
; 59: 101594, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-35232622
3.
Differential interaction with TREM2 modulates microglial uptake of modified Aß species.
Glia
; 69(12): 2917-2932, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34427354
4.
The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.
EMBO J
; 36(13): 1837-1853, 2017 07 03.
Artigo
Inglês
| MEDLINE | ID: mdl-28559417
5.
A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity.
Acta Neuropathol
; 127(5): 667-83, 2014 May.
Artigo
Inglês
| MEDLINE | ID: mdl-24531916
6.
Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
Mol Neurodegener
; 19(1): 18, 2024 Feb 17.
Artigo
Inglês
| MEDLINE | ID: mdl-38365827
7.
APOE-ε4 synergizes with sleep disruption to accelerate Aß deposition and Aß-associated tau seeding and spreading.
J Clin Invest
; 133(14)2023 07 17.
Artigo
Inglês
| MEDLINE | ID: mdl-37279069
8.
Sleep deprivation exacerbates microglial reactivity and Aß deposition in a TREM2-dependent manner in mice.
Sci Transl Med
; 15(693): eade6285, 2023 04 26.
Artigo
Inglês
| MEDLINE | ID: mdl-37099634
9.
Glitter in the Darkness? Nonfibrillar ß-Amyloid Plaque Components Significantly Impact the ß-Amyloid PET Signal in Mouse Models of Alzheimer Disease.
J Nucl Med
; 63(1): 117-124, 2022 01.
Artigo
Inglês
| MEDLINE | ID: mdl-34016733
10.
Activated microglia mitigate Aß-associated tau seeding and spreading.
J Exp Med
; 218(8)2021 08 02.
Artigo
Inglês
| MEDLINE | ID: mdl-34100905
11.
TREM2 modulates differential deposition of modified and non-modified Aß species in extracellular plaques and intraneuronal deposits.
Acta Neuropathol Commun
; 9(1): 168, 2021 10 18.
Artigo
Inglês
| MEDLINE | ID: mdl-34663480
12.
Microbiota-derived short chain fatty acids modulate microglia and promote Aß plaque deposition.
Elife
; 102021 04 13.
Artigo
Inglês
| MEDLINE | ID: mdl-33845942
13.
The Alzheimer's disease-associated protective Plcγ2-P522R variant promotes immune functions.
Mol Neurodegener
; 15(1): 52, 2020 09 11.
Artigo
Inglês
| MEDLINE | ID: mdl-32917267
14.
Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model.
EMBO Mol Med
; 12(2): e10919, 2020 02 07.
Artigo
Inglês
| MEDLINE | ID: mdl-31858749
15.
Asymmetry of Fibrillar Plaque Burden in Amyloid Mouse Models.
J Nucl Med
; 61(12): 1825-1831, 2020 12.
Artigo
Inglês
| MEDLINE | ID: mdl-32414948
16.
Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region.
EMBO Mol Med
; 12(4): e11227, 2020 04 07.
Artigo
Inglês
| MEDLINE | ID: mdl-32154671
17.
Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism.
EMBO Mol Med
; 11(6)2019 06.
Artigo
Inglês
| MEDLINE | ID: mdl-31122931
18.
Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE.
Nat Neurosci
; 22(2): 191-204, 2019 02.
Artigo
Inglês
| MEDLINE | ID: mdl-30617257
19.
Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models.
Sci Rep
; 6: 19880, 2016 Jan 27.
Artigo
Inglês
| MEDLINE | ID: mdl-26813748